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Peptide stability in research settings

This quick guide explains how pH, temperature, light, and handling can influence degradation in a laboratory environment. It supports the calculator below so researchers can make informed storage decisions in vitro.

Key factors that affect peptide stability

• Temperature. Refrigeration and freezing reduce kinetic activity, which slows degradation. Avoid repeated freeze–thaw cycles.
• pH. Very acidic or alkaline conditions can increase hydrolysis or side reactions. Neutral pH is generally more stable for many sequences.
• Light and oxygen. UV exposure and oxidative stress can accelerate breakdown. Store out of light with suitable closures.
• Matrix. Lyophilised powders usually show longer stability than reconstituted solutions in research conditions.

Tip: Use the calculator to view a stability window for your chosen form, temperature, and pH. Results are generalised for research. Not for human or veterinary use.